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MTF2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 162081AP

Catalog No. 50-173-0791


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Description

Description

Polycomb group (PcG) that specifically binds histone H3 trimethylated at  ft.Lys-36 ft. (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter
Specifications

Specifications

MTF2
0.29 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q02395, Q9Y483
hPCl2, M96, MTF2, PCL2, Polycomb like protein 2, RP5 976O13.1
Rabbit
IgG
150 μL
-20°C
Primary
17765, 22823, 360905
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
MTF2
Liquid
Mtf2
MTF2 Fusion Protein Ag9182
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Documents
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