MYC Mouse anti-Human, Clone: 9E10.3, Abnova™
Mouse monoclonal antibody raised against synthetic peptide of human MYC.
Manufacturer: Abnova Corporation MAB13378
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq]Sequence: AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA
|Mouse monoclonal antibody raised against synthetic peptide of human MYC.|
|In 10mM PBS.|
|Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing.
|This monoclonal antibody shows no cross-reaction with v-myc.|
|Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed)|
|Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL) Immunofluorescence (1-2 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL) The optimal working dilution should be determined by the end user.|
|A synthetic peptide (conjugated with KLH) corresponding to amino acids 408-439 at C-terminus region of human MYC.|
|Protein A/G purification|
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