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MYH11 Mouse anti-Human, Clone: SPM201, Abnova™

Mouse monoclonal antibody raised against native human MYH11.

Manufacturer:  Abnova Corporation MAB13124

Catalog No. 89-934-645


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Description

Description

The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

Specifications

Specifications

MYH11
SPM201
Mouse monoclonal antibody raised against native human MYH11.
In 10mM PBS.
AAT4/DKFZp686D10126/DKFZp686D19237/FAA4/FLJ35232/MGC126726/MGC32963/SMHC/SMMHC
Mouse
IgG1, kappa
100 ug
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing.
Monoclonal
Human
Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed)
Unconjugated
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.
Liquid
MYH11
Human uterus extract.
Protein A/G purification
RUO
Primary
4629
SDS
Documents
Product Certifications
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