DescriptionMYH7 encodes the beta myosin heavy chain (MHC-β) which is a component of cardiac muscle myosin mainly expressed in the ventricle of fetal heart and represents the minority myosin in the adult heart. This is the 'slow form' of cardiac myosin as opposed to the 'fast form' (MYH6, aka MHC-α) expressed more predominantely in the atria of the fetal heart and is the predominant myosin in the adult heart. The two isoforms of cardiac MHCα and β display 93% homology but have significantly different enzymatic properties, with α having 150-300% the contractile velocity and 60-70% actin attachment time as that of β. Several mutations in MYH7 have been associated with inherited cardiomyopathies paraspinal and proximal muscle atrophy. MYH7 is a 223kDa protein composed of 1935 amino acids.
|Immunocytochemistry, Western Blot|
|Protein A or G purified from cell culture supernatant|
|Supplied as a solution in PBS containing BSA, Glycerol and Sodium Azide. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with Sodium Azide|
|Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.|
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