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Medchemexpress LLC N-(4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl)-3-(4-fluorophenyl)pyrimidine-5-carboxamide | 1437321-24-8 | 99.6% | 588.56 | C31H26F2N4O6 | 1 G
SDP

Supplier:  Medchemexpress LLC HY1009461G

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CEP-40783 is a potent, selective, orally available small-molecule inhibitor of the receptor tyrosine kinases AXL and c-Met. It exhibits low-nanomolar biochemical potency, enhanced cellular activity, high kinome selectivity, and has shown dose-dependent target inhibition and antitumor efficacy in preclinical in vivo models.

  • Potent biochemical activity: AXL IC50 of 7 nM and c-Met IC50 of 12 nM.
  • Enhanced cellular potency in model cell lines (AXL-transfected 293GT IC50 ≈ 0.26 nM; GTL-16 c-Met IC50 ≈ 6 nM).
  • High kinome selectivity with S90 = 0.04 against 298 kinases.
  • Demonstrated dose- and time-dependent target inhibition and tumor regressions in xenograft studies.
  • Supplied for research use with high reported purity.

Catalog No. 50-002-12593


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