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N,N-Dimethylsphingosine, Tocris Bioscience™

Catalog No. 464010
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Quantity:
10 mg
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This item is not returnable. View return policy

Description

Sphingosine kinase inhibitor

Competitive sphingosine kinase (SphK) inhibitor. Exhibits inhibitory activity in platelets and in cytosolic extracts from U937, Swiss 3T3 and PC12 cells. Selectively inhibits sphingosine phosphorylation; does not inhibit N-acylation, and displays no inhibitory effect on protein kinase C at concentrations that inhibit SphK. Increases the release of IL-1β and MCP-1 in cultured astrocytes; thought to mediate mechanical allodynia via this mechanism.

Chemical Identifiers

CAS 119567-63-4
Molecular Formula C20H41NO2
Molecular Weight (g/mol) 327.553
InChI Key YRXOQXUDKDCXME-QWKHPXNBSA-N
Synonym n,n-dms, unii-l9qra71834, nn-dimethyl-d-erythrosphingosine, 4-octadecene-1,3-diol, 2-dimethylamino-, s-r*,s*-e, d0os7u, n,n-dimethylsphingosine tlc, e,2r,3s-2-dimethylaminooctadec-4-ene-1,3-diol, e,2r,3s-2-dimethylamino octadec-4-ene-1,3-diol, 2r,3s,4e-2-dimethylamino-4-octadecene-1,3-diol, e,2r,3s-2-dimethylamino-octadec-4-ene-1,3-diol
PubChem CID 6438166
IUPAC Name (E,2R,3S)-2-(dimethylamino)octadec-4-ene-1,3-diol
SMILES CCCCCCCCCCCCCC=CC(C(CO)N(C)C)O

Specifications

Quantity 10 mg
Formula Weight 327.55
Percent Purity >98%
Chemical Name or Material N, N-Dimethylsphingosine

Safety and Handling

Recommended Storage Store at -20°C
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