N4BP2L2 Monoclonal Antibody (OTI3F12), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA804204

Catalog No. 50-168-0128

Description

N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein that potentially is involved in transcriptional regulation. N4BP2L2 is phosphorylated on Ser 199 in response to DNA damage, probably by ATM or ATR. Primarily expressed in bone marrow, N4BP2L2 is dramatically down-regulated after exposure to arsenic compounds, an event which precedes neutropenia. PFAAP5 interacts with both Gfi-1 and Neutrophil Elastase, two proteins that are implicated in neutropenia disorders. Defects in the gene encoding Neutrophil Elastase, ELA2, are the cause of cyclic haematopoiesis, which, with decreased numbers of circulating neutrophils, leads to an increased risk for opportunistic infection.

Specifications

• Antigen: N4BP2L2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q92802
• Gene Symbols: N4BP2L2
• Immunogen: Full length human recombit protein of human N4BP2L2 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Western Blot
• Clone: OTI3F12
• Conjugate: Unconjugated
• Gene: N4BP2L2
• Gene Alias: 92M18.3, CG005, CG016, PFAAP5
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10443
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid