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N4BP2L2 Mouse anti-Human, Clone: OTI1C8, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526655

Catalog No. PIMA526655


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Description

Description

N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein that potentially is involved in transcriptional regulation. N4BP2L2 is phosphorylated on Ser 199 in response to DNA damage, probably by ATM or ATR. Primarily expressed in bone marrow, N4BP2L2 is dramatically down-regulated after exposure to arsenic compounds, an event which precedes neutropenia. PFAAP5 interacts with both Gfi-1 and Neutrophil Elastase, two proteins that are implicated in neutropenia disorders. Defects in the gene encoding Neutrophil Elastase, ELA2, are the cause of cyclic haematopoiesis, which, with decreased numbers of circulating neutrophils, leads to an increased risk for opportunistic infection.
Specifications

Specifications

N4BP2L2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q92802
NEDD4-binding protein 2-like 2, Phosphonoformate immuno-associated protein 5, CG005, PFAAP5
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
10443
Immunohistochemistry (Paraffin), Western Blot
OTI1C8
Unconjugated
N4BP2L2
Liquid
N4BP2L2
Full length human recombit protein of N4BP2L2 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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