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N6AMT2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 169541AP

Catalog No. 50-173-1291


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Description

Description

Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintece of methylation. Dnmt2 contains all the sequence motifs diagnostic of DNA (cytosine-5)-methyltransferases but appears to lack the large N-terminal regulatory domain common to other eukaryotic methyltransferases.
Specifications

Specifications

N6AMT2
0.13 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q8WVE0, Q9CY45
ESP13, N6AMT2
Rabbit
IgG
150 μL
-20°C
Primary
221143, 290279, 68043
Western Blot
Unconjugated
EEF1AKMT1
Liquid
Eef1akmt1
N6AMT2 Fusion Protein Ag10589
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Documents
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