NAB2 Mouse anti-Human, Clone: OTI3H5, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526637
DescriptionTranscriptional control is in part regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (for NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2, are corepressors of EGF-1/NGFI-A. Both NAB1 and NAB2 contain an amino terminal NAB conserved domain 1 (NCB1), which is required for binding NGFI-A, and a carboxy terminal NCD2 domain, which is responsible for the repressor function of NAB proteins. NAB2 is principally localized in the nucleus and may play a role in the downregulation of NGFI-A activity as well as in controlling fundamental processes such as cell division, differentiation and apoptosis. NAB2 has a predicted molecular mass of 56 kDa and localizes to chromosome 12q13.3-14.1, a region that is rearranged in several solid tumors, lipomas and liposarcomas.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|MADER, EGR-1-binding protein 2, EGR1 binding protein 2, NGFI-A-binding protein 2, melanoma-associated delayed early response protein|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 178-442 of NAB2 produced in E.coli|
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