Invitrogen™ NLRP6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA521022

Catalog No. PIPA521022

Description

A suggested positive control is human heart tissue lysate. PA5-21022 can be used with blocking peptide PEP-1136.

NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC. Co-expression of NALP6 with ASC results in a synergistic activation of NF-kappa-B and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.

Specifications

• Antigen: NLRP6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NLRP6
• Gene Alias: AI504961; angiotensin II/vasopressin receptor; angiotensin/vasopressin receptor; AVR; CLR11.4; dual angiotensin II/vasopressin receptor; NACHT, leucine rich repeat and PYD containing 6; NACHT, LRR and PYD domains-containing protein 6; NACHT/LRR/pyrin domain-containing protein 6; NALP6; Navr; Navr/Avr; NLR family pyrin domain containing 6; NLR family, pyrin domain containing 6; Nlrp6; Non-angiotensin-vasopressin receptor; Non-AVR; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6; PAN3; Pypaf5; PYRIN-containing APAF1-like protein 5; PYRIN-containing APAF1-like protein 5-like
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 171389
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P59044
• Gene Symbols: NLRP6
• Immunogen: A 16 amino acid peptide near the amino terminus of human NALP6.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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