NANOS3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 216791AP
Descriptionos is a zinc-finger containing, RNA-binding protein that has been implicated in germ cell development in both invertebrates and vertebrates. In Drosophila, os represses apoptosis during development to ensure proper germ-line development. Unlike os1 whose expression in mice is dispensable, the os2 and os3 proteins are required for germ cell development. os2-null primordial germ cells (PGCs) die only in the male gonads and show no defects in females, while os3-null PGCs are lost during the migration stage regardless of sex. os2 and os3 have distinct expression patterns during embryo development, suggesting that these two proteins do not have redundant functions. However, expression of os2 can at least partially replace os3 function in a os3-null background. os3 expression can not rescue os2-null defects.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|os homolog 3, os homolog 3 (Drosophila), NANOS1L, NANOS3, NOS 3, NOS3|
|244551, 288909, 342977|
|Immunohistochemistry (Paraffin), Western Blot|
|NANOS3 Fusion Protein Ag16014|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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