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NAT1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA595422
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Synthetic peptide sequence: 172-201aa, NEEFLHSDLLEDSKYRKIYSFTLKPRTIED. Reconstitution information: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.Arylamine N-acetyltransferases (NAT-1 and NAT-2) catalyze N- or O-acetylation of heterocyclic and arylamine substrates in the detoxification of a wide array of drugs. Certain alleles causing high N-acetyltransferase activity have been associated with colon and urinary bladder cancers, as NATs also bioactivate several known carcinogens. Both NAT-1 and NAT-2 are cytoplasmic proteins and play an active role in the detoxification of many arylamine and hydrazine drugs. N-acetylation polymorphism is determined by the level of NAT activity in liver tissues, and has been linked to the action and toxicity of drugs that contain amines. Human NAT-1 is the functional homolog of rodent NAT-2, while human NAT-2 is the functional homolog of rodent NAT-1.
|0.2mg sodium phosphate with 0.9MG NaCl, 0.9MG NaCl and 0.05MG sodium azide, 0.05MG sodium azide|
|A synthetic peptide corresponding to a sequence at the C-terminus of human NAT1, different from the related mouse sequence by six amino acids, and from the related rat sequence by five amino acids.|
|Arylamine N-acetyltransferase 1; 220.127.116.11; Arylamide acetylase 1; Monomorphic arylamine N-acetyltransferase; MNAT; N-acetyltransferase type 1; NAT-1; NAT1; AAC1|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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