NCAPH2 Monoclonal Antibody (5F2G4), Active Motif™

Rat Monoclonal Antibody

Supplier:  Active Motif 61681

Catalog No. 50-199-3614

Description

Structural maintenance of chromosomes (SMC) and non-SMC condensin proteins associate into complexes that have been implicated in the process of chromosome condensation. A crucial prerequisite for accurate segregation of replicated sister chromatids is the condensation of the chromosomes into a manageable form prior to metaphase. The condensin I complex consists of two SMC subunits, SMC2 and SMC4, and three non-SMC subunits, CAP-H, CAP-G, and CAP-D2. An alternative complex, the condensin II complex, contains alternate non-SMC subunits, CAP-G2, CAP-H2, and CAP-D3. CAP-H2 is also known as Non-SMC condensin II complex, subunit H2 (NCAPH2) or kleisin beta isoform 2. The three non-SMC subunits in the condensing complexes form a regulatory subcomplex that is required to activate the SMC ATPases and to promote mitosis-specific chromatin binding of the holocomplex. The precise individual functions of each non-SMC protein in activation remain to be determined.

Specifications

• Antigen: NCAPH2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
• Gene Accession No.: Q6IBW4
• Gene Symbols: NCAPH2
• Immunogen: This antibody was raised against a recombinant protein to human NCAPH2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Clone: 5F2G4
• Conjugate: Unconjugated
• Gene: NCAPH2
• Gene Alias: CAPH2; CAP-H2 subunit of the condensin II complex; Chromosome-associated protein H2; Condensin-2 complex subunit H2; CTA-384D8.36; D15Ertd785e; hCAP-H2; kleisin beta; Kleisin-beta; NCAPH2; Non-SMC condensin II complex subunit H2; non-SMC condensin II complex, subunit H2
• Host Species: Rat
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 29781
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid