NCAPH2 Rat anti-Human, Clone: 5F2G4, Active Motif™
Rat Monoclonal Antibody
Manufacturer: Active Motif 61682
DescriptionStructural maintenance of chromosomes (SMC) and non-SMC condensin proteins associate into complexes that have been implicated in the process of chromosome condensation. A crucial prerequisite for accurate segregation of replicated sister chromatids is the condensation of the chromosomes into a manageable form prior to metaphase. The condensin I complex consists of two SMC subunits, SMC2 and SMC4, and three non-SMC subunits, CAP-H, CAP-G, and CAP-D2. An alternative complex, the condensin II complex, contains alternate non-SMC subunits, CAP-G2, CAP-H2, and CAP-D3. CAP-H2 is also known as Non-SMC condensin II complex, subunit H2 (NCAPH2) or kleisin beta isoform 2. The three non-SMC subunits in the condensing complexes form a regulatory subcomplex that is required to activate the SMC ATPases and to promote mitosis-specific chromatin binding of the holocomplex. The precise individual functions of each non-SMC protein in activation remain to be determined.
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 30% glycerol and 0.035% sodium azide; pH 7.5|
|CAPH2; CAP-H2 subunit of the condensin II complex; Chromosome-associated protein H2; Condensin-2 complex subunit H2; CTA-384D8.36; D15Ertd785e; hCAP-H2; kleisin beta; Kleisin-beta; NCAPH2; Non-SMC condensin II complex subunit H2; non-SMC condensin II complex, subunit H2|
|This antibody was raised against a recombinant protein to human NCAPH2.|
|-20°C, Avoid Freeze/Thaw Cycles|
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