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NCF4 Mouse anti-Human, Clone: OTI4B5, lyophilized, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner CF809135

Catalog No. 50-166-9292


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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Specifications

Specifications

NCF4
Monoclonal
Unconjugated
NCF4
Lyophilized
NCF4
Full length human recombit protein of human NCF4 produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Immunohistochemistry (Paraffin), Western Blot
OTI4B5
PBS with 8% trehalose and no preservative; pH 7.3
Q15080
CGD3, NCF, P40PHOX, SH3PXD4
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
4689
SDS
Documents
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