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NDP Rabbit anti-Human, Mouse, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 153801AP

Catalog No. 50-173-0190


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Description

Description

This antibody detects 11-15 kDa (monomer) and 48 kDa (polymers).

Norrie disease is an X-linked genetic disorder characterized by progressive atrophy of the eyes, mental disturbances and deafness. The gene responsible for this disease was initially identified through positional cloning. Norrin, the gene product, encodes a small secreted, cysteine-rich protein that is thought to act as a ligand for the Wnt-receptor/beta-catenin signal pathway despite having sequence homology with the Wnt family of proteins. Mice lacking this gene have abnormal blood vessel growth in the vitreous and a disorganized retina, transgenic ectopic expression of Norrin restores normal retinal vasculature. Recent evidence shows that Norrin can attenuate tPA and uPA-mediated death of transformed rat retinal ganglion cells (RGC-5) by activating the Wnt/beta-catenin pathway and regulating the phosphorylation of LRP-1, a cell surface receptor for tPA and uPA, suggesting the Norrin may function in vivo by regulating kinases which may alter the phosphorylation of LRP-1.
Specifications

Specifications

NDP
0.3 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P48744, Q00604
EVR2, FEVR, ND, NDP, Norrie disease (pseudoglioma), Norrie disease protein, Norrin
Rabbit
IgG
150 μL
-20°C
Primary
17986, 4693
Western Blot
Unconjugated
NDP
Liquid
Ndp
NDP Fusion Protein Ag4066
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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