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  6. Nebivolol hydrochloride, Tocris Bioscience™

Nebivolol hydrochloride, Tocris Bioscience™

Catalog Number 351710
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
152520-56-4
C22H26ClF2NO4
445.924
JWEXHQAEWHKGCW-PZFCLNQZSA-N
(±)-[2R™(1S™5S™(S™))]-α, α'-[Iminobis(methylene)bis(6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-methanol)
131674192
(1S)-2,2-dideuterio-2-[[(2S)-1,1-dideuterio-2-[(2R)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]amino]-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol;hydrochloride
C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O.Cl
This item is not returnable. View return policy
152520-56-4
C22H26ClF2NO4
445.924
JWEXHQAEWHKGCW-PZFCLNQZSA-N
(±)-[2R™(1S™5S™(S™))]-α, α'-[Iminobis(methylene)bis(6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-methanol)
131674192
(1S)-2,2-dideuterio-2-[[(2S)-1,1-dideuterio-2-[(2R)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]amino]-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol;hydrochloride
C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O.Cl

Description

Highly selective β1-adrenoceptor antagonist

Highly selective β1-adrenoceptor antagonist (Ki values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at β1, 5-HT1A, β2, 5-HT2, α1, H1 and D2 receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC50 = 11.36 μM in renal arteries) and displays antihypertensive activity in vivo. GRK/β -arrestin biased agonist at the β2 adrenoceptor.
Quantity 10 mg
Formula Weight 441.9
Percent Purity >98%
Chemical Name or Material Nebivolol hydrochloride

Safety and Handling

Recommended Storage Desiccate at Room Temperature
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