Manufacturer: Tocris 5025/10
DescriptionNecroptosis inhibitor. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors.
- Chemical Name: (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide
- Formula: C18H15N5O6S2
- CAS Number: 1360614-48-7
- Solubility: Soluble to 20mM in DMSO
- Purity: >98
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