Invitrogen™ NEDD4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA526930

Catalog No. PIPA526930

Description

This antibody is predicted to react with rat based on sequence homology.

The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein. It contains one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It is involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. It acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53. It is also reported to be involved in the budding of many viruses and is the regulator of epithelial Na+ channels, which lead to arterial hypertension. NEDD4 protein is localized to the sarcolemmal region of muscle fibers. Increase in NEDD4 protein expression leads to unloaded and denervated muscles as well as a decrease in Notch1 expression. Hence it acts as down regulator of Notch-1 gene expression.

Specifications

• Antigen: NEDD4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NEDD4
• Gene Alias: AA959633; AL023035; AU019897; cell proliferation-inducing gene 53 protein; E3 ubiquitin-protein ligase NEDD4; E430025J12Rik; HECT-type E3 ubiquitin transferase NEDD4; Kiaa0093; mKIAA0093; NEDD4; NEDD-4; NEDD4 E3 ubiquitin protein ligase; Nedd4-1; Nedd4a; Neural precursor cell expressed developmentally down-regulated protein 4; neural precursor cell expressed, developmentally down-regulated 4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase; neural precursor cell expressed, developmentally down-regulated gene 4; neural precursor cell expressed, developmentally down-regulated gene 4a; neural precursor cell expressed, developmentally down-regulted gene 4; OTTHUMP00000217840; OTTHUMP00000217841; OTTHUMP00000217842; PIG53; receptor-potentiating factor 1; RPF1
• Host Species: Rabbit
• Purification Method: Ammonium Sulfate Precipitation, Size-exclusion - Dialysis
• Regulatory Status: RUO
• Gene ID (Entrez): 17999, 4734
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: P46934, P46935
• Gene Symbols: NEDD4
• Immunogen: KLH conjugated synthetic peptide between 1288-1319 amino acids from the C-terminal region of human NEDD4.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG