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NEIL3 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA551022

Catalog No. PA551022


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Description

Description

NEIL3 Polyclonal Antibody detects endogenous levels of NEIL3 protein.

DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair. {ECO:0000269; PubMed:12433996, ECO:0000269; PubMed:19170771, ECO:0000269; PubMed:22569481, ECO:0000269; PubMed:23755964}.
Specifications

Specifications

NEIL3
Polyclonal
Unconjugated
NEIL3
Liquid
NEIL3
Synthesized peptide derived from the C-terminal region of human NEIL3.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
ELISA, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
Q8TAT5, Q8K203
FGP2, FLJ10858, FPG2, NEI3, hFPG2, hNEI3
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
234258, 55247
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