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Nesprin 1 Mouse anti-Human, Clone: OTI1E10, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527519

Catalog No. PIMA527519


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Description

Description

There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus. These proteins are called nesprin-l and -2 for nuclear _envelope _spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM-domain-containing sequence essential for perinuclear localization. Nesprin-l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as  ft.dystrophins of the nucleus ft. to maintain nuclear organization and structura integrity.
Specifications

Specifications

Nesprin 1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q8NF91
SYNE 1; RP1-130E4.2; 8B; ARCA1; C6orf98; CPG2; DKFZp781J13156; EDMD4; FLJ30878; FLJ41140; KIAA0796; KIAA1262; KIAA1756; MYNE1; SCAR8; dJ45H2.2; Enaptin; Myocyte nuclear envelope protein 1; Myne-1; Nuclear envelope spectrin repeat protein 1; Synaptic nuclear envelope protein 1
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
23345
Immunohistochemistry (Paraffin), Western Blot
OTI1E10
Unconjugated
SYNE1
Liquid
SYNE1
Human recombit protein fragment corresponding to amino acids 1-285 of SYNE1 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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