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Tocris™ NESS 0327

Ultra-high affinity and selective CB1 antagonist

Supplier:  Tocris™ 5746/50

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Catalog No. 57-465-0


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Description

Description

NESS 0327 is an ultra-high affinity and selective CB1 receptor antagonist (Ki = 350 fM). Exhibits >60-fold selectivity for CB1 over CB2 receptors. Antagonizes the inhibitory effects of WIN 55,212-2 (Cat. No. 1038) on electrically evoked contractions in mouse isolated vas deferens ex vivo. Also antagonizes the antinociceptive effect of WIN 55,212-2 in tail-flick and hot plate tests in vivo.
Specifications

Specifications

8-Chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydro-N-1-piperidinyl-benzo[6,7 ]cyclohepta[1,2-c]pyrazole-3-carboxamide
50 mg
C24H23Cl3N4O
98%
494844-07-4
Cannabinoid R1/CB1 Antagonists
7676
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Safety and Handling

Recommended Storage : Store at -20°C

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