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Tocris™ NESS 0327

Ultra-high affinity and selective CB1 antagonist

$243.33 - $1021.11

Specifications

Molecular Formula C24H23Cl3N4O
Purity 98%
Target Cannabinoid R1/CB1 Antagonists
Chemical Name or Material 8-Chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydro-N-1-piperidinyl-benzo[6,7 ]cyclohepta[1,2-c]pyrazole-3-carboxamide
CAS 494844-07-4
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
57-461-0
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Tocris™
5746/10
10 mg
Each for $243.33
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57-465-0
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Tocris™
5746/50
50 mg
Each for $1,021.11
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Description

Description

Ultra-high affinity and selective CB1 receptor antagonist (Ki = 350 fM). Exhibits ∽60-fold selectivity for CB1 over CB2 receptors. Antagonizes the inhibitory effects of WIN 55,212-2 (Cat. No. 1038) on electrically evoked contractions in mouse isolated vas deferens ex vivo. Also antagonizes the antinociceptive effect of WIN 55,212-2 in tail-flick and hot plate tests in vivo.
Specifications

Specifications

C24H23Cl3N4O
Cannabinoid R1/CB1 Antagonists
494844-07-4
98%
8-Chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydro-N-1-piperidinyl-benzo[6,7 ]cyclohepta[1,2-c]pyrazole-3-carboxamide
Safety and Handling

Safety and Handling

Recommended Storage : Store at -20°C

SDS
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