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Tocris™ NESS 0327
Ultra-high affinity and selective CB1 antagonist
$243.33 - $1021.11
Specifications
| Molecular Formula | C24H23Cl3N4O |
|---|---|
| Purity | 98% |
| Target | Cannabinoid R1/CB1 Antagonists |
| Chemical Name or Material | 8-Chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydro-N-1-piperidinyl-benzo[6,7 ]cyclohepta[1,2-c]pyrazole-3-carboxamide |
| CAS | 494844-07-4 |
Description
Ultra-high affinity and selective CB1 receptor antagonist (Ki = 350 fM). Exhibits ∽60-fold selectivity for CB1 over CB2 receptors. Antagonizes the inhibitory effects of WIN 55,212-2 (Cat. No. 1038) on electrically evoked contractions in mouse isolated vas deferens ex vivo. Also antagonizes the antinociceptive effect of WIN 55,212-2 in tail-flick and hot plate tests in vivo.Specifications
| C24H23Cl3N4O | |
| Cannabinoid R1/CB1 Antagonists | |
| 494844-07-4 |
| 98% | |
| 8-Chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydro-N-1-piperidinyl-benzo[6,7 ]cyclohepta[1,2-c]pyrazole-3-carboxamide |
Safety and Handling
Recommended Storage : Store at -20°C
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