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NeuN Rabbit anti-Human, Mouse, Porcine, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 269751AP

Catalog No. 50-114-2787


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Description

Description

NeuN (Fox-3, NEUN, HRNBP3, RBFOX3, RNA binding protein, fox-1) or Fox-1 homolog C, is a 350 amino acid protein that contains one RRM (RNA recognition motif) domain. Localized to both the nucleus and cytoplasm, Fox-3 is suggested to regulate alternative splicing events. Fox-3 is encoded by a gene located on human chromosome 17, which is comprised over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintece of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with maligt cell growth and LiFraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determit of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
Specifications

Specifications

NeuN
0.37 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
A6NFN3, Q8BIF2
FOX3, Homo sapiens (Human), HRNBP3, NeuN, RBFOX3
Rabbit
IgG
150 μL
-20°C
Primary
110256156, 146713, 287847, 52897
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
RBFOX3
Liquid
Rbfox3
NeuN Fusion Protein Ag25689
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Porcine, Rat
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