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neurturin Rabbit anti-Human, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 197091AP

Catalog No. 50-173-2503


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Description

Description

The antibody is specific to NRTN.

Glial cell line-derived neurotrophic factor (GDNF) plays key roles in the control of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin. Physiological responses to neurturin (NTN) require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNRalpha. The cDNAs encoding NTNRalpha from human, rat, chicken, and mouse have been cloned recently and termed GDNFR-b, Ret ligand 2 (RETL2) or TGF-beta-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFR-a-2 recently. NTN binds to and forms a complex with GFR-a-2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations. Neurturin and GDNF define a new family of neurotrophic factors.
Specifications

Specifications

neurturin
0.35 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q99748
neurturin, NRTN, NTN
Rabbit
IgG
150 μL
-20°C
Primary
4902
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
NRTN
Liquid
NRTN
Peptide
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
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