NFS1 Mouse anti-Human, Clone: OTI2H5, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526740
DescriptionNFS1 (nitrogen fixation 1), also known as NIFS or IscS (cysteine desulfurase), is a member of the class V pyridoxal-phosphate-dependent aminotransferase family. It localizes to the cytoplasm or mitochondrion depending on which form is generated based on cytosolic pH. Highest expression levels of NFS1 are found in heart and skeletal muscle. Lower levels of expression are also found in liver, brain and pancreas. NFS1 is responsible for catalyzing the removal of sulfur from cysteine to form alanine, thereby supplying the inorganic sulfur for iron-sulfur (Fe-S) clusters. Fe-S clusters function as essential cofactors in a wide variety of events, including facilitation of electron transfer processes in oxidative phosphorylation, catalysis of enzymatic reactions in aconitase and dehydratases and maintece of structural integrity in the DNA repair enzyme endonuclease III.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|NFS1 nitrogen fixation 1 homolog (S. cerevisiae), IscS, NIFS, HUSSY-08|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 1-299 of NFS1 produced in E.coli|
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