Invitrogen™ NGB Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110027

Catalog No. PIPA5110027

Description

Immunogen sequence: MERPEPELIR QSWRAVSRSP LEHGTVLFAR LFALEPDLLP LFQYNCRQFS SPEDCLSSPE FLDHIRKVML VIDAAVTNVE DLSSLEEYLA SLGRKHRAVG VKLSSFSTVG ESLLYMLEKC LGPAFTPATR AAWSQLYGAV VQAMSRGWDG E.

Globins are a superfamily of gas-binding heme proteins that are present in bacteria, protists, fungi, plants and animals. Globins play evolutionarily divergent roles which include binding, transport, scavenging, detoxification, and sensing of oxygen, nitric oxide and carbon monoxide. Neuroglobin (Ngb) is a hexacoordinate hemoglobin that is predominantly expressed in the vertebrate brain and may enhance oxygen supply to neural components. Neuroglobin displays a high affinity for oxygen and its presence in cerebral neurons suggests a role in neuronal responses to hypoxia or ischemia. For example, in vitro neuronal hypoxia causes an elevation in the levels of neuroglobin, which enhances neuronal cell survival. The human neuroglobin gene maps to chromosome 14q24 and encodes a 151 amino acid protein.

Specifications

• Antigen: NGB
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NGB
• Gene Alias: Neuroglobin; NGB
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 58157, 64242
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.29 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9ER97, Q9NPG2
• Gene Symbols: NGB
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-151 of human NGB (NP_0670801).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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