NGEF Rabbit anti-Human, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA549485
DescriptionActs as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.
|PBS with 0.09% sodium azide|
|Ephexin-1, Eph-interacting exchange protein, Neuronal guanine nucleotide exchange factor, NGEF|
|-20° C, Avoid Freeze/Thaw Cycles|
|KLH conjugated synthetic peptide between 187-220 amino acids from the N-terminal region of human NGEF.|
|Antigen Affinity Chromatography, Protein A|
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