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NGEF Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549485

Catalog No. PA549485


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Description

Description

Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.
Specifications

Specifications

NGEF
Polyclonal
PBS with 0.09% sodium azide
Q8N5V2, Q5BKC9
Ephexin-1, Eph-interacting exchange protein, Neuronal guanine nucleotide exchange factor, NGEF
Rabbit
IgG
200 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
246217, 25791
Western Blot
Unconjugated
NGEF
Liquid
NGEF
KLH conjugated synthetic peptide between 187-220 amino acids from the N-terminal region of human NGEF.
Antigen Affinity Chromatography, Protein A
RUO
Antibody
Polyclonal
Human, Rat
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