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  8. NH 125, Tocris Bioscience™

NH 125, Tocris Bioscience™

Catalog Number 343950
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
278603-08-0
C27H45IN2
524.575
RVWOHCBHAGBLLT-UHFFFAOYSA-M
1-benzyl-3-cetyl-2-methylimidazolium iodide, eef-2 kinase inhibitor, nh125, 1-hexadecyl-2-methyl-3-phenylmethyl-1h-imidazolium iodide, nh hplc , solid, 1-benzyl-3-hexadecyl-2-methylimidazol-1-ium iodide
10436839
1-benzyl-3-hexadecyl-2-methylimidazol-1-ium;iodide
CCCCCCCCCCCCCCCCN1C=C[N+](=C1C)CC2=CC=CC=C2.[I-]
This item is not returnable. View return policy
278603-08-0
C27H45IN2
524.575
RVWOHCBHAGBLLT-UHFFFAOYSA-M
1-benzyl-3-cetyl-2-methylimidazolium iodide, eef-2 kinase inhibitor, nh125, 1-hexadecyl-2-methyl-3-phenylmethyl-1h-imidazolium iodide, nh hplc , solid, 1-benzyl-3-hexadecyl-2-methylimidazol-1-ium iodide
10436839
1-benzyl-3-hexadecyl-2-methylimidazol-1-ium;iodide
CCCCCCCCCCCCCCCCN1C=C[N+](=C1C)CC2=CC=CC=C2.[I-]

Description

CaM kinase III (eEF-2 kinase) inhibitor

Eukaryotic elongation factor 2 (eEF-2) kinase (CaMK III) inhibitor (IC50 = 60 nM) that displays 125-fold, > 1300-fold and > 1500-fold selectivity over PKC, PKA and CaMK II respectively. Decreases the viability of a variety of cancer cell lines (IC50 values are 0.7 - 4.8 μM) and blocks G1/S cell cycle progression. Shown to induce eEF-2 phosphorylation in cancer cells. Also an effective antibacterial agent; inhibits histidine protein kinase in vitro (IC50 = 6.6 μM) and in vivo.
Quantity 50 mg
Formula Weight 524.56
Percent Purity >98%
Chemical Name or Material NH 125

Safety and Handling

Recommended Storage Desiccate at -20°C
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