NIPA Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA551026
NIPA Polyclonal Antibody detects endogenous levels of NIPA protein.Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
|Synthesized peptide derived from human NIPA around the non-phosphorylation site of S354.|
|Antigen affinity chromatography|
|Human, Mouse, Non-human primate, Rat|
|ELISA, Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4|
|-20° C, Avoid Freeze/Thaw Cycles|
|232679, 296957, 51530|
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