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NIPA Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA551026

Catalog No. PA551026


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Description

Description

NIPA Polyclonal Antibody detects endogenous levels of NIPA protein.

Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
Specifications

Specifications

NIPA
Polyclonal
Unconjugated
ZC3HC1
Liquid
ZC3HC1
Synthesized peptide derived from human NIPA around the non-phosphorylation site of S354.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Non-human primate, Rat
ELISA, Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
Q86WB0, Q80YV2
NIPA
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
232679, 296957, 51530
Documents
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