NKG2A/NKG2C/NKG2E Rat anti-Mouse, PE, Clone: 20d5, Invitrogen
Rat Monoclonal Antibody
Manufacturer: Invitrogen A15417
DescriptionNatural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed.
|PBS with 0.1% sodium azide|
|Klrc1, Klrc2, Klrc3|
|epitope common to the NKG2A, NKG2C and NKG2E isoforms of the CD94/NKG2 heterodimer|
|CD159A, NKG2, NKG2A, C-lectin type II protein, CD159 antigen-like family member A, NK cell receptor A, NKG2-1/B activating NK receptor, NKG2-A/B type II integral membrane protein, NKG2-A/B-activating NK receptor, NKG2-A/NKG2-B type II integral membrane protein, natural killer cell l, KLRC1|
|16641, 16642, 58179|
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