NKG2D/CD314 Mouse anti-Human, Clone: 1D11, Novus Biologicals™

Mouse Monoclonal Antibody has been used in 3 publications

Supplier:  Novus Biologicals NB100659560.05MG

Catalog No. NB017762

Description

NKG2D/CD314 Monoclonal specifically detects NKG2D/CD314 in Human samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, CyTOF-ready, Functional Assay.

Specifications

• Antigen: NKG2D/CD314
• Classification: Monoclonal
• Concentration: 1.0 mg/mL
• Dilution: Flow Cytometry 1:50-1:200, Immunohistochemistry 1:10-1:500, Immunocytochemistry/Immunofluorescence, Immunoprecipitation 1:10-1:500, Immunohistochemistry-Paraffin 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500, CyTOF-ready, Functional Assay
• Gene Accession No.: P26718
• Gene Symbols: KLRK1
• Immunogen: NKL cells.
• Quantity: 0.05 mg
• Primary or Secondary: Primary
• Test Specificity: NB100-65956 is specific for CD314, also known as natural killer receptor G2 (NKG2D) and as killer cell lectin-like receptor subfamily K, member 1 (KLRK1). CD314 is a C-type lectin-like activating receptor which is expressed on most natural killer (NK) cells, CD8 T cells and gamma delta T cells. CD314 forms homodimers that signal through an associated DAP10 adaptor protein. Ligands of CD314 include MICA, MICB and UL16 binding protein (ULBP), which are inducibly expressed. Ligand binding to CD314 results in NK cell activation and potent costimulation of effector T cells. Clone 1D11 is reported to inhibit T cell recognition of MICA (1,6).
• Content And Storage: Store at -20C. Avoid freeze-thaw cycles.
• Isotype: IgG1

• Applications: Immunohistochemistry (Frozen), Functional Assay, CyTOF, Immunohistochemistry, Immunoprecipitation, Immunocytochemistry, Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
• Clone: 1D11
• Conjugate: Unconjugated
• Formulation: Phosphate buffered saline with No Preservative
• Gene Alias: CD314, CD314 antigen, D12S2489E, FLJ17759, FLJ75772, Killer cell lectin-like receptor subfamily K member 1, killer cell lectin-like receptor subfamily K, member 1, KLR, NK cell receptor D, NKG2-D, NKG2-D type II integral membrane protein, NKG2-D-activating NK receptor, NKG2DDNA segment on chromosome 12 (unique) 2489 expressed sequence
• Host Species: Mouse
• Purification Method: Protein A purified
• Regulatory Status: RUO
• Gene ID (Entrez): 22914
• Target Species: Human
• Form: Purified

For Research Use Only