NKIRAS1 Monoclonal Antibody (OTI8A3), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA505395

Catalog No. 50-167-5878

Description

KappaB ras-1 (kappa-B-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with Ikappa-B (Ikappa-B), an inhibitor of the transcription factor NF-kappa-B. Ikappa-B exists in two homologous forms, Ikappa-B-alpha and Ikappa-B-beta, although Ikappa-B-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive Ikappa-B-alpha-NF-kappa-B complexes can shuttle in and out of the nucleus, Ikappa-B-beta-NF-kappa-B complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the Ikappa-B-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of Ikappa-B-beta and regulating the rate of degradation of Ikappa-B-beta.

Specifications

• Antigen: NKIRAS1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q9NYS0
• Gene Symbols: NKIRAS1
• Immunogen: Full length human recombit protein of human NKIRAS1 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Western Blot
• Clone: OTI8A3
• Conjugate: Unconjugated
• Gene: NKIRAS1
• Gene Alias: KBRAS1, kappaB-Ras1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 28512
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid