Invitrogen™ NKp44 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547279

Catalog No. PIPA547279

Description

In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human (rh) NKp30, rhNKp46, and rhNKp80 is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <1.5 EU per 1 μg of the antibody by the LAL method.

CD336 is also known as NKp44 or NCR2. CD336 is a 44-kDa transmembrane glycoprotein belonging to the natural cytotoxicity receptor (NCR) family and contains an ITIM domain located in the cytoplasmic tail. Expression of CD336 and NK cell activation by the receptor requires association with DAP12, an ITAM-containing transmembrane accessory protein. Once thought to be expressed exclusively on IL-2-activated NK cells and a subset of gamma delta T lymphocytes, studies have shown expression of CD336 on IL-3-stimulated plasmacytoid dendritic cells, alpha beta T cells in the small intestinal epithelium, and T cells in cord blood. CD336 has been shown to be involved in the innate response of activated NK cells against viral infection and tumor cell proliferation.

Specifications

• Antigen: NKp44
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NCR2
• Gene Alias: CD336; CD336 antigen; dJ149M18.1; LY95; lymphocyte antigen 95 (activating NK-receptor; NK-p44); Lymphocyte antigen 95 homolog; lymphocyte antigen 95 homolog (activating NK-receptor; NK-p44); natural cytotoxicity triggering receptor 2; Natural killer cell p44-related protein; natural killer cell receptor; NCR2; NK cell activating receptor (NKp44); NK cell-activating receptor; NKP44; NK-p44; NK-p44dJ149M18.1
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9436
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Functional Assay, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: O95944
• Gene Symbols: NCR2
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human NKp44/NCR2 Gln22-Pro190, predicted.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG