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NLRX1 Mouse anti-Human, Clone: OTI4H8, lyophilized, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner CF809764

Catalog No. 50-166-9703


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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

NLR family member X1 (NLRX1) belongs to the NLRP family and contains four LRR (leucine-rich) repeats and one NATCH domain. NLRX1 localizes to the mitochondrial outer membrane and interacts through the mitochondrial antiviral signalling adaptor MAVS during viral infection. Expression of NLRX1 results in the potent inhibition of RLH- and MAVS-mediated interferon-beta promoter activity and in the disruption of virus-induced RLH-MAVS interactions. It is also reported that NLRX1 synergistically potentiated ROS production induced by tumour necrosis factor alpha, Shigella infection and double-stranded RNA, resulting in amplified NF-kappaB-dependent and JUN amino-terminal kinases-dependent signalling, thus contributing to the link between ROS generation at the mitochondria and innate immune responses.
Specifications

Specifications

NLRX1
Monoclonal
Unconjugated
NLRX1
Lyophilized
NLRX1
Human recombit protein fragment corresponding to amino acids 866-975 of human NLRX1 produced in E.coli.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Immunohistochemistry (Paraffin), Western Blot
OTI4H8
PBS with 8% trehalose and no preservative; pH 7.3
Q86UT6
CLR11.3, DLNB26, NOD26, NOD5, NOD9
Mouse
IgG2b
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
79671
SDS
Documents
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