NLRX1 Mouse anti-Human, Clone: OTI4H8, lyophilized, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene CF809764
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCONLR family member X1 (NLRX1) belongs to the NLRP family and contains four LRR (leucine-rich) repeats and one NATCH domain. NLRX1 localizes to the mitochondrial outer membrane and interacts through the mitochondrial antiviral signalling adaptor MAVS during viral infection. Expression of NLRX1 results in the potent inhibition of RLH- and MAVS-mediated interferon-beta promoter activity and in the disruption of virus-induced RLH-MAVS interactions. It is also reported that NLRX1 synergistically potentiated ROS production induced by tumour necrosis factor alpha, Shigella infection and double-stranded RNA, resulting in amplified NF-kappaB-dependent and JUN amino-terminal kinases-dependent signalling, thus contributing to the link between ROS generation at the mitochondria and innate immune responses.
|Human recombit protein fragment corresponding to amino acids 866-975 of human NLRX1 produced in E.coli.|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 8% trehalose and no preservative; pH 7.3|
|CLR11.3, DLNB26, NOD26, NOD5, NOD9|
|-20° C, Avoid Freeze/Thaw Cycles|
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