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NME3 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549708

Catalog No. PA549708


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Description

Description

The antibody detects endogenous level of total NME3 protein.

NME3 mRNA is preferentially expressed at early stages of myeloid differentiation of highly purified CD34(+) cells. Its constitutive expression in a myeloid precursor line, which is growth-factor dependent for both proliferation and differentiation, results in inhibition of granulocytic differentiation induced by granulocyte colony-stimulating factor and causes apoptotic cell death. These results appear consistent with a role for the NME3 gene in normal hematopoiesis and raise the possibility that its overexpression contributes to differentiation arrest, a feature of blastic transformation in chronic myelogenous leukemia.
Specifications

Specifications

NME3
Polyclonal
Unconjugated
NME3
Liquid
NME3
Full length fusion protein of Human NME3
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
ELISA, Western Blot
1.2 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q13232, Q9WV85
NME/NM23 nucleoside diphosphate kinase 3, NDPKC, NDPK-C, NM23H3, DR-nm23, NM23-H3, c371H6.2
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
4832, 79059
Documents
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