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Nod2 Rat anti-Mouse, Clone: 26mNOD2, eBioscience™ Non-distribution product as customer accommodation.

Rat Monoclonal Antibody

Manufacturer:  Invitrogen 14585881

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Catalog No. 50-132-21


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Description

Description

Description: The monoclonal antibody 26mNOD2 reacts with mouse NOD2. NOD2, also referred to as caspase recruitment domain-containing protein 15 (CARD 15), is a cytosolic protein of approximately 115kDa. NOD2 contains a central NOD (nucleotide oligomerization domain) that is flanked by a C-terminal leucine-rich repeat (LRR) domain and an N-terminal CARD domain. The LRR confers recognition of microbial components such as muramyl dipeptide and the CARD domain confers the ability to interact with RIP2 via homotypic interaction with the RIP2 CARD. This interaction leads to downstream activation of NF-kappaB. The antibody 26mNOD2 has been shown to recognize protein from transgenic and transfected cells. Refer to references for expression in endogenous cells. Applications Reported: This 26mNOD2 antibody has been reported for use in immunoblotting (WB). Applications Tested: This 26mNOD2 antibody has been tested by immunoblotting of lysates of 293T cells transfected with mouse NOD2. This antibody has been validated on transfected cell lines and cells from NOD2-transgenic mice. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 µm post-manufacturing filtered.

NOD2 is a member of the apoptosis regulating protein family that includes caspase recruitment-domains, as well as Apaf-1 and NOD1. It contains two N-terminal CARDs, a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). NOD2 is expressed in monocytes (whereas NOD1 is expressed in multiple tissues). NOD2 plays a role in regulating NF-kappaB, acts as an intracellular receptor for bacterial lipopolysaccharides, and contributes to inflammatory bowel disease (IBD) and Crohn ft.s disease.
Specifications

Specifications

Nod2
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q8K3Z0
NOD-2, NOD 2, CARD15, Caspase recruitment domain protein 15, IBD1, Inflammatory Bowel disease protein 1
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Western Blot
26mNOD2
Unconjugated
Nod2
Liquid
Nod2
IgG1, kappa
50 μg
4° C
Primary
257632
SDS
Documents
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