BioVision Inc Nitric Oxide Synthase (NOS) Inhibitor Screening Kit (Fluorometric): Simple, fast, fluorometric assay to screen/study/charecterize potential NOS inhibitors
Manufacturer: BioVision Inc K208100
Nitric Oxide Synthase (NOS) Inhibitor Screening Kit (Fluorometric): Introduction: Nitric oxide synthases (EC 188.8.131.52) (NOS) is a family of enzymes that catalyze the production of nitric oxide (NO). NO has also been associated with numerous pathological situations such as hypotension accompanying septic shock, essential hypertension, and atherosclerosis. Therefore, developing small molecules for inhibition of NOS is therapeutically desirable. BioVision's Nitric Oxide Synthase Inhibitor Screening Kit provides a simple and high-throughput adaptable method to screen/study/characterize potential NOS inhibitors. In this assay, nitric oxide generated by NOS undergoes a series of reactions and reacts with the fluorescent probe to generate a stable signal at Ex/Em = 360/450 nm, which is directly proportional to NOS activity. In the presence of a NOS-specific inhibitor, the formation of NO is reduced/abolished resulting in decrease or total loss of the fluorescence.
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