Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double stranded RNA (dsRNA) that is produced during the replicative life cycle of a majority of viruses. Poly(I:C) is known to induce type-1 interferon (IFN) through TLR3. Poly(I:C) directly binds to TLR3.
- Species: Human, Mouse
- Stimulation of TLR3 can be achieved with 10-100μg/mL
|Used for Activation of TLR3. Stimulation of TLR3 Can be Achieved with 10-100 µg/mL Use in In Vitro Assay Reported in Scientific Literature (PMID 24743304) .Use in Ligand Activation, and Functional Reported in Scientific Literature (PMID 25957979). Use in In Vivo Assay Reported in Scientific Literature (PMID 26196739). Use in Ligand Activation Reported in Scientific Literature (PMID 26503951)|
|Store at 4 C short term. Aliquot and store (at -20 C long term. Avoid freeze-thaw cycles.)|