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NOX4 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA588106

Catalog No. PIPA588106


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Description

Description

Positive Samples: U2OS; Cellular Location: Cell junction, Cell membrane, Endoplasmic reticulum membrane, Multi-pass membrane protein, Nucleus, focal adhesion, nucleolus Immunogen sequence: KENFKARPGQ YITLHCPSVS ALENHPFTLT MCPTETKATF GVHLKIVGDW TERFRDLLLP PSSQDSEILP FIQSRNYPKL YIDGPFGSPF EESLNYEVSL CVAGGIGVTP FASILNTLLD DWKPYKLRRL YFIWVCRDIQ SFRWFADLLC MLHNKFWQEN RPDYVNIQLY LSQTDGIQKI IGEKYHALNS RLFIGRPRWK LLFDEIAKYN RGKTVGVFCC GPNSLSKTLH KLSNQNNSYG TRFEYNKESF S

Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

NOX4
Polyclonal
Unconjugated
Nox4
AI648021, kidney oxidase-1, Kidney superoxide-producing NADPH oxidase, KOX, KOX1, KOX-1, NADPH oxidase 4, NOX 4, NOX4, NOX-4, renal NAD(P)H-oxidase, RENOX, superoxide-generating NADPH oxidase 4
Rabbit
Affinity Chromatography
RUO
50490, 50507, 85431
-20° C, Avoid Freeze/Thaw Cycles
Liquid
Immunohistochemistry (Paraffin), Western Blot
0.12 mg/mL
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Q924V1, Q9JHI8, Q9NPH5
Nox4
A synthetic peptide corresponding to a sequence within amino acids 328-578 of human NADPH oxidase 4 (NOX4) (NP_0586271)
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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