NOX4 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA588106

Catalog No. PIPA588106

Description

Immunogen sequence: KENFKARPGQ YITLHCPSVS ALENHPFTLT MCPTETKATF GVHLKIVGDW TERFRDLLLP PSSQDSEILP FIQSRNYPKL YIDGPFGSPF EESLNYEVSL CVAGGIGVTP FASILNTLLD DWKPYKLRRL YFIWVCRDIQ SFRWFADLLC MLHNKFWQEN RPDYVNIQLY LSQTDGIQKI IGEKYHALNS RLFIGRPRWK LLFDEIAKYN RGKTVGVFCC GPNSLSKTLH KLSNQNNSYG TRFEYNKESF S; Positive Samples: U2OS; Cellular Location: Cell junction, Cell membrane, Endoplasmic reticulum membrane, Multi-pass membrane protein, Nucleus, focal adhesion, nucleolus

Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.

Specifications

• Antigen: NOX4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NOX4
• Gene Symbols: Nox4
• Immunogen: Recombit fusion protein containing a sequence corresponding to amino acids 328-578 of human NOX4
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Concentration: 2.97 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9JHI8, Q9NPH5
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 50507, 50490
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid