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NPM1, Mouse anti-Human, Alexa Fluor 350, Clone: NPM1/3287, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus Biologicals NBP279876AF350

Catalog No. NB011604


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Description

Description

NPM1 Monoclonal antibody specifically detects NPM1 in Human samples. It is validated for Western Blot, ELISA, Immunohistochemistry, Immunohistochemistry (Paraffin).
Specifications

Specifications

NPM1
NPM1/3287
Western Blot, ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin
Conjugated, Purified
NPM1
Recombinant human NPM1 protein fragment (aa185-287) (exact sequence is proprietary)
Protein A or G purified
RUO
Store at 4°C in the dark.
Monoclonal
Human
ELISA, Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot
Alexa Fluor 350
50mM Sodium Borate with 0.05% Sodium Azide
B23, MGC104254, NPMnucleophosmin/nucleoplasmin family, member 1, Nucleolar phosphoprotein B23, Nucleolar protein NO38, nucleophosmin, nucleophosmin (nucleolar phosphoprotein B23, numatrin), numatrin
Mouse
IgG2b Kappa
0.1 mL
Apoptosis, Cancer, Cell Cycle and Replication, Chromatin Research, DNA replication Transcription Translation and Splicing, Mitotic Regulators, Phospho Specific, Signal Transduction, Tumor Suppressors
Primary
This antibody recognizes a 33kDa glycoprotein, identified as Nucleophosmin (NPM1). It is predominantly localized in the nucleus of cells in most tissues. NPM1 is involved in ribosomal assembly and rRNA transport. It is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis. This phosphoprotein moves between the nucleus and the cytoplasm. It is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location. Mutations in this gene are associated with acute myeloid leukemia. The antibody may be a useful aid for classification of acute myeloid leukemia.
SDS
Documents
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