Tocris™ NPS 2143 hydrochloride

Selective antagonist of the calcium-sensing receptor; orally active calcilytic agent

Manufacturer: Tocris™ 3626/10

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Catalog No. 36-261-0R

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For Research Use Only


    Product Type NPS 2143 hydrochloride
    Inhibitors NPS 2143 hydrochloride
    Purity >99
    Molecular Weight 445.38
    Quantity 10mg

    Selective Ca2+-sensing receptor antagonist. Blocks increases in cytoplasmic Ca2+ concentrations elicited by human Ca2+ receptors expressed in HEK293 cells (IC50 = 43nM). Also stimulates parathyroid hormone secretion from bovine parathyroid cells (EC50 = 41nM). Orally active calcilytic compound.

    • Chemical Name: 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino-2-hydroxypropoxy]benzonitrile hydrochloride
    • Formula: C24H25ClNO2.HCl
    • CAS Number: 324523-20-8
    • Solubility: Soluble to 100mM in DMSO and to 10mM in ethanol
    • Purity: >99

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