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NR0B1 Mouse anti-Human, Clone: OTI5F5, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526709

Catalog No. PIMA526709


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Description

Description

AHC has been mapped to chromosome Xp21 at the same or close to an X-linked locus involved in sex determination, DSS (for dosage-sensitive sex reversal). The gene corresponding to DSS and AHC (designated DAX-1 for DSS-AHC critical region on the X chromosome, gene 1) has been cloned and shown to be deleted in AHC deletion patients and mutated in AHC non-deletion patients. The carboxy terminal 250 amino acids of the DAX-1-encoded protein, DAX-1, exhibits approximately 50% continuous similarity to the ligand-binding domain of the members of the nuclear hormone receptor superfamily while the amino terminal domain contains a putative DNA-binding motif. DAX-1 binds to retinoic acid responsive elements and down regulates retinoic acid receptor-mediated transcriptional activation.
Specifications

Specifications

NR0B1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P51843
AHC, AHCH, AHX, DAX-1, DAX1, DSS, GTD, HHG, NROB1, SRXY2, DSS-AHC critical region on the X chromosome protein 1, nuclear hormone receptor, nuclear receptor DAX-1, nuclear receptor DAX1, nuclear receptor subfamily 0 group B member 1
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
190
Immunohistochemistry (Paraffin), Western Blot
OTI5F5
Unconjugated
NR0B1
Liquid
NR0B1
Human recombit protein fragment corresponding to amino acids 161-430 of NR0B1 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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