NR0B2 Mouse anti-Human, Clone: OTI5F10, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526785
DescriptionThe protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|NR0B2;NR0B2_HUMAN;Nr0b2a;Nuclear receptor subfamily 0 group B member 2;Nuclear receptor subfamily 0, group B, member 2a;Orphan nuclear receptor SHP;SHP;SHP-1;Shp1;Small heterodimer partner;|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of NR0B2 produced in E.coli|
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