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NR0B2 Mouse anti-Human, Clone: OTI7B5, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526786

Catalog No. PIMA526786


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Description

Description

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
Specifications

Specifications

NR0B2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q15466
NR0B2;NR0B2_HUMAN;Nr0b2a;Nuclear receptor subfamily 0 group B member 2;Nuclear receptor subfamily 0, group B, member 2a;Orphan nuclear receptor SHP;SHP;SHP-1;Shp1;Small heterodimer partner;
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
8431
Immunohistochemistry (Paraffin), Western Blot
OTI7B5
Unconjugated
NR0B2
Liquid
NR0B2
Full length human recombit protein of NR0B2 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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