NR1H4 Mouse anti-Human, Clone: OTI4F12, lyophilized, TrueMAB™ 

Mouse Monoclonal Antibody

Manufacturer:  OriGene CF809306

Catalog No. 50-166-9402

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and bind DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, as well as several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed orphan receptors because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.

Specifications

• Antigen: NR1H4
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: NR1H4
• Format: Lyophilized
• Gene Symbols: NR1H4
• Immunogen: Human recombit protein fragment corresponding to amino acids 21-297 of human NR1H4 produced in E.coli.
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Monoclonal
• Target Species: Human

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI4F12
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q96RI1
• Gene Alias: BAR, FXR, HRR-1, HRR1, PFIC5, RIP14
• Host Species: Mouse
• Isotype: IgG1
• Quantity: 100 μg
• Storage Requirements: -20° C, Avoid Freeze/Thaw Cycles
• Primary or Secondary: Primary
• Gene ID (Entrez): 9971