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NR1H4 Mouse anti-Human, Clone: OTI4F12, lyophilized, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner CF809306

Catalog No. 50-166-9402


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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and bind DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, as well as several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed orphan receptors because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.
Specifications

Specifications

NR1H4
Monoclonal
Unconjugated
NR1H4
Lyophilized
NR1H4
Human recombit protein fragment corresponding to amino acids 21-297 of human NR1H4 produced in E.coli.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Immunohistochemistry (Paraffin), Western Blot
OTI4F12
PBS with 8% trehalose and no preservative; pH 7.3
Q96RI1
BAR, FXR, HRR-1, HRR1, PFIC5, RIP14
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
9971
SDS
Documents
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