Invitrogen™ NRL Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA537003

Catalog No. PIPA537003

Description

This antibody detects endogenous protein at a molecular weight of 30 kDa. Purity is >95% by SDS-PAGE.

Nrl (neural retina leucine zipper) is a member of the Maf family of transcription factors, which characteristically contain a highly conserved basic leucine zipper (bZIP)-DNA binding motif. Both Nrl and c-Maf preferentially bind to T-MARE sites and are implicated in a wide variety of developmental and physiologic roles. The Maf-Nrl subfamily regulates the expression of cell type-specific genes in tissues of the hematopoietic system, cerebellum and developing hindbrain. Maf and Nrl proteins bind an extended AP-1-like sequence and can form heterodimers with Fos and Jun transcription factors. In retinal cells and photoreceptor cells, Nrl promotes the expression of rhodopsin through binding to the Nrl response element present in the rhodopsin promoter. Nrl is expressed throughout the developing central and peripheral nervous system during neuronal differentiation, and its expression is restricted to neocortex, brainstem and retinal neurons during adulthood.

Specifications

• Antigen: NRL
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NRL
• Gene Alias: D14H14S46E; D14S46E; neural retina leucine zipper; neural retina leucine zipper gene; neural retinal-specific leucine zipper; neural retina-specific leucine zipper protein; Nrl; NRL-MAF; RP27
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18185, 290221, 4901
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P54845, P54846
• Gene Symbols: NRL
• Immunogen: Synthetic peptide corresponding to amino acids 42-87 of human NRL.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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