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NSC 74859, Tocris Bioscience™

Catalog Number p-4817109
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
501919-59-1
C16H15NO7S
365.356
HWNUSGNZBAISFM-UHFFFAOYSA-N
2-hydroxy-4-2-tosyloxy acetamido benzoic acid, unii-jg1e8503oi, stat3 inhibitor vi, s3i-201, salicylic acid, 4-p-toluenesulfonate, 2-hydroxy-4-2-4-methylphenyl sulfonyl oxy acetyl amino benzoic acid, 2-hydroxy-4-2-4-methylbenzenesulfonyl oxy acetamido benzoic acid, benzoic acid, 2-hydroxy-4-2-4-methylphenyl sulfonyl oxy acetyl amino, s3i hplc, 2-hydroxy-4-2-p-tolylsulfonyloxy acetyl amino benzoic acid
252682
2-hydroxy-4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid
CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O
This item is not returnable. View return policy
501919-59-1
C16H15NO7S
365.356
HWNUSGNZBAISFM-UHFFFAOYSA-N
2-hydroxy-4-2-tosyloxy acetamido benzoic acid, unii-jg1e8503oi, stat3 inhibitor vi, s3i-201, salicylic acid, 4-p-toluenesulfonate, 2-hydroxy-4-2-4-methylphenyl sulfonyl oxy acetyl amino benzoic acid, 2-hydroxy-4-2-4-methylbenzenesulfonyl oxy acetamido benzoic acid, benzoic acid, 2-hydroxy-4-2-4-methylphenyl sulfonyl oxy acetyl amino, s3i hplc, 2-hydroxy-4-2-p-tolylsulfonyloxy acetyl amino benzoic acid
252682
2-hydroxy-4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid
CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O

Selective STAT3 inhibitor

NSC 74859 selectively inhibits STAT3 DNA-binding activity in vitro (IC50 values are 86, 160, and >300 μM for STAT3-STAT3, STAT1-STAT3 and STAT1-STAT1 DNA-binding activity respectively). NSC 74859 blocks growth and induces apoptosis preferentially in tumor cells that contain persistently active STAT3 in vitro and arrests tumor growth in a murine xenograft model in vivo.
Quantity 10 mg
Formula Weight 365.36
Percent Purity >98%
Chemical Name or Material NSC 74859
Recommended Storage Store at -20°C
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